Beilstein J. Org. Chem.2021,17, 1392–1439, doi:10.3762/bjoc.17.98
methodologies and the biological applications of double-headed nucleosides.
Keywords: acyclic double-headed nucleosides; bicyclic double-headed nucleosides; furanosyldouble-headednucleosides; modified nucleosides; pyranosyl double-headed nucleosides; Introduction
Nucleosides are the constructional subunits
structured based on the types of the sugar moiety of the nucleoside and the position of the attachment of the additional base, either directly or through a linker on the sugar.
Review
Furanosyldouble-headednucleosides
Based on literature reports most of the double-headed nucleosides comprised a
on the position of the attachment of the additional nucleobase/heterocyclic system at the particular carbon of the pentofuranosyl moiety of the nucleoside (Figure 1).
1,2-Furanosyldouble-headednucleosides
Herein, all nucleosides comprising furanosyl ring structures are included, with the first
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Graphical Abstract
Figure 1:
Double-headed nucleosides. B1 and B2 = nucleobases or heterocyclic/carbocyclic moieties; L = linker....